Monophosphoryl Lipid a as an adjuvant for immune therapy? A detailed in vitro comparison to LPS
نویسندگان
چکیده
منابع مشابه
Monophosphoryl Lipid a as an adjuvant for immune therapy? A detailed in vitro comparison to LPS
Monophosphoryl lipid A (MPL) is a non-toxic TLR4 ligand, derived from Salmonella minnesota R595 (Re) lipopolysaccharide (LPS) by chemical modification. It is clinically used as an adjuvant for cancer treatment (Fendrix, Ceravix) and allergen specific immunotherapy (Pollinex Quattro, ORALVAC). Nevertheless, reports on the mechanism of adjuvant activity are limited. The aim of this study was to c...
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چکیده ندارد.
15 صفحه اولRole of innate immune factors in the adjuvant activity of monophosphoryl lipid A.
Monophosphoryl lipid A (MPL) is a nontoxic derivative of lipopolysaccharide (LPS) that exhibits adjuvant properties similar to those of the parent LPS molecule. However, the mechanism by which MPL initiates its immunostimulatory properties remains unclear. Due to the involvement of Toll-like receptors in recognizing and transducing intracellular signals in response to LPS, the aim of the presen...
متن کاملSA-4-1BBL and monophosphoryl lipid A constitute an efficacious combination adjuvant for cancer vaccines.
Vaccines based on tumor-associated antigens (TAA) have limited therapeutic efficacy due to their weak immunogenic nature and the various immune evasion mechanisms active in advanced tumors. In an effort to overcome these limitations, we evaluated a combination of the T-cell costimulatory molecule SA-4-1BBL with the TLR4 agonist monophosphoryl lipid A (MPL) as a novel vaccine adjuvant system. In...
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ژورنال
عنوان ژورنال: Clinical and Translational Allergy
سال: 2014
ISSN: 2045-7022
DOI: 10.1186/2045-7022-4-s2-o21